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Assessing the Feasibility, Usability and Acceptability of the MySafeRx Platform Among Individuals in Outpatient Buprenorphine Treatment: Lessons Learned from A Pilot Randomized Controlled Trial


Janzow GE, Harding C, Flores M, et al.


To examine the feasibility, usability, and acceptability of MySafeRx, a mobile platform featuring recovery coaching based on Motivational Interviewing. MySafeRx is delivered via videoconference alongside medication adherence monitoring and electronic pill dispensing in support of outpatient buprenorphine/naloxone (B/N) treatment for Opioid Use Disorder.


A pilot randomized controlled trial was conducted to assess the addition of MySafeRx to standard care for outpatient B/N treatment. Adult participants (ages 18 to 65) receiving treatment for Opioid Use Disorder who report illicit opioid use or have a urine toxicology positive for illicit opioids or miss a urine toxicology in the past 30 days were recruited from Hawthorne Treatment Center and Cambridge Health Alliance. Participants randomized to the Intervention group received 6 weeks of MySafeRx mobile intervention in addition to standard care. Standard care consisted of in-person office-based B/N treatment. Mobile recovery coaches were trained in Motivational Interviewing techniques and adherence monitoring. All participants were asked to complete online weekly feasibility surveys to assess the frequency of B/N supervised self-administration; participants using MySafeRx also completed weekly online surveys to capture platform acceptability (i.e., satisfaction with MySafeRx) and usability (i.e., competency using MySafeRx).


• Almost half (n=25; 44%) of referrals declined to participate due to a perceived lack of need for
additional monitoring or coaching.
• Twenty-seven recruited participants enrolled (100% White, average age=31.9 years, 63% female).
• MySafeRx participants reported an average usability score of 78.4 (i.e., adequate usability is at
least a score of 68) and found the electronic pill dispenser (Mean = 4.1 out of 5) and
videoconferencing with recovery coaches “easy to use” (Mean = 4.2 out of 5).
• Participants indicated they would recommend MySafeRx to a friend (Mean= 4.1 out of 5).
• Recovery coaching had the highest acceptability of all components (Mean= 4.4 out of 5).
• MySafeRx coaches reported supervising participants’ self-administration of B/N on 64.3% of study
days, which was less than the anticipated 71% (i.e., 5 of 7 days per week).


• Although the sample size was small, those who participated in this pilot found MySafeRx to be acceptable with favorable usability.
• These findings provide insight into the need for and promise of mobile recovery coaching, particularly during periods of instability in standard B/N care.
• MySafeRx could be a useful tool for future telemedicine OUD implementation projects.

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Janzow GE, Harding C, Flores M, et al. Assessing the feasibility, usability and acceptability of the MySafeRx platform among individuals in outpatient buprenorphine treatment: Lessons learned from a pilot randomized controlled trial. Drug Alcohol Depend Rep. 2022 Mar 17;3:100045. doi: 10.1016/j.dadr.2022.100045