Funding Source
NIDA Clinical Trials Network (NIH HEAL Initiative), CTN-0100
Project Period
6/8/21 – 12/30/26
Principal Investigator
Edward Nunes, MD (Columbia University Irving Medical Center); John Rotrosen, MD (NYU School of Medicine); Roger Weiss, MD (McLean Hospital)
Other Project Staff
CTBH Collaborators:
Luke Archibald, MD (Northeast Node/Dartmouth Health Addiction Treatment Program Site Principal Investigator (PI)); Lisa A. Marsch, PhD (Northeast Node Principal Investigator); Chantal Lambert-Harris, MA (Northeast Node Project Manager); Laurie Lester, PhD (Northeast Node Quality Assurance/Regulatory Specialist); Janet Cobb, MPH, MSN, APRN (Dartmouth Health Addiction Treatment Program Site Medical Clinician); Bryan Hybki, MD (Dartmouth Health Addiction Treatment Program Site Medical Clinician)
Project Summary
This study will (1) test strategies to improve retention and treatment outcomes among patients in outpatient medication treatment for opioid use disorder (MOUD), (2) test strategies to improve outcomes among patients who have achieved stable remission and want to discontinue MOUD and (3) develop models to predict who is able to discontinue MOUD without relapse.
Public Health Relevance
Dropout of treatment is a major barrier to the effectiveness of medication treatment for opioid use disorder. This study will reveal new insights into novel strategies to enhance treatment retention as well as strategies to improve long-term treatment outcomes among individuals who choose to discontinue medication treatment for opioid use disorder.